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Archived from the original on 6 September A number of genes have been positively associated with the skin pigmentation difference between European and non-European populations. Firstly, the UVA-radiation creates oxidative stress, which in turn oxidizes existing melanin and leads to rapid darkening of the melanin, also known as IPD immediate pigment darkening. These ancient civilizations viewed relations between the major power and the subordinate state as more significant in a person's status than their skin colors. Modern lifestyles and mobility have created mismatch between skin color and environment for many individuals.

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Tanning response in humans is controlled by a variety of genes. For more than an hour, dark-skinned black women shared their feelings of rejection, sexual objectification and marginalisation. Both the amount and type of melanin produced is controlled by a number of genes that operate under incomplete dominance. There is a long-standing hypothesis that the selection for lighter skin due to higher vitamin D absorption occurred soon after the Out of Africa migration some time before 40, years ago. Identification, structure and consequences of polymorphic variation". One melanocyte supplies melanin to thirty-six keratinocytes according to signals from the keratinocytes.

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